TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells
Summary:
In order to investigate the specific characteristics influenced by the activation of TLR9 in wounds, we employed the single-cell RNA sequencing (scRNA-seq) to visually compare immune cells and inflammatory factors and cytokines under the influence of TLR9.
Overall Design:
Dorsal skin healed from large circular wound (diameter=1.8cm) of the C57/BL6 mice were collected and analyzed using scRNAseg.
Cell Clustering
Color UMAP by
Switch between fine-grained and coarse annotations
Loading UMAP…
Enrichment Analysis
Enrichment mode
Select enrichment collection
Top pathways
Ranked by absolute NES
Differentially Expressed Genes
p-value threshold0.05
Maximum adjusted p-value
Log fold change1.0
Minimum log₂ fold change
Cell type group
Filter by cell type
Gene
logFC
p-value
Score
Group
CellPhoneDB Cell-Cell Communication Analysis
Dynamic Analysis
Select Cell Types
Choose 2 or more cell types to analyze ligand-receptor interactions