tissue: scalp disease state: AA preservation: frozen age (rounded): 35 Sex: F
Experiment Information
Title:
Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease [scRNA-Seq]
Summary:
In this study, we use single-cell ATAC sequencing (scATAC-seq) and single-cell RNA sequencing (scRNA-seq) to map chromatin accessibility and gene expression in human scalp samples from healthy patients and patients with alopecia areata
Overall Design:
We generated single-cell ATAC-seq and single-cell RNA-seq libraries from human scalp tissue from three sources: punch biopsy samples from healthy control volunteers (C_PB, n = 3), punch biopsies from patients with clinically active alopecia areata (AA, n = 5), and discarded normal peripheral surgical tissue from patients undergoing dermatologic surgeries on the scalp (C_SD, n = 7)
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